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This led to the hypothesis that other cannabinoid compounds were interfering with 9-THC's effects. Specifically, it was shown that CBD was able to block the excitatory effects of 9-THC and to potentate the depressant effects of 9-THC (Karniol and Carlini, 1973, Psychopharmacologia 33: 53) while.

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Specifically, the pharmaceutical composition is prepared by mixing isolated, purified or synthetic CBD with isolated, purified or synthetic 8-THC at a ratio of 2-10 parts 8-THC to 1 part CBD. As will be apparent to one knowledgeable in the art, the specific dosage may vary.

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For example, 8-THC is a double bond isomer of 9-THC and is a minor constituent of most varieties of Cannabis (Hollister and Gillespie, 1972, Clin Pharmacol Ther 14: 353). The major chemical difference between the two compounds is that 9-THC is easily oxidized to cannabinol.

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